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anticipated absolute effects: quit rates with monotherapy 137 per 1000, quit rates with combination NRT 174 per 1000 NICE guidance on stop smoking medicines: 8 NRT monotherapy: recommended as second line treatment NRT combination therapy: recommended as first line treatment Cytisine: Under consultation to add as first line treatment Varenicline: recommended as first line treatment Bupropion: recommended as second line treatment Cytisine: Cytisine increases chances of quitting vs placebo/no treatment27 Varenicline: Varenicline increases chances of quitting vs placebo/no treatment27 Bupropion: Bupropion increases chances of quitting vs placebo27 Bupropion has lower quit rates than Combination NRT (RR 0.74 [95% CI: 0.55 to 0.98])28 To keep in mind: No robust data to differentiate NRT combination therapy and cytisine or varenicline quit rates NRT combination therapy has higher quit rates than bupropion NRT, cytisine, varenicline and bupropion are effective for quitting smoking Understanding your patients needs and lifestyle can help you determine the right treatment option for them *with the 7 formats NRT is the most prescribed treatment for smoking cessation 29 Nicorette: Nicorette is suitable for: - Adolescents 12 years old and plus 7

Cigarette smoke-induced DNA-damage: role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine