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In a study of apoptotic responses to TNF in cancer lines, GPx1 was shown to decrease thioredoxin oxidation to maintain the inactive thioredoxin-ASK1 complex by reducing ROS, as measured by DCF fluorescence

That hormone turned out to be ghrelin, purified from rat stomach in 1999: a 28-amino-acid peptide bearing an unusual octanoyl (fatty-acid) modification on its third serine residue, a modification essential for its GH-releasing activity

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