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In a sucrose-fed rat model, where animals developed significantly lower aortic tissue glutathione and higher aortic tissue oxidised glutathione (GSSG) compared with controls, 1 % v/v GLY offered in drinking water for 4 weeks restored glutathione levels in vascular tissue and significantly reduced markers of oxidative damage

10.1016/j.cell.2012.03.042 43

Anti-inflammation biomaterial platforms for chronic wound healing

doi: 10.1146/annurev-cellbio-120219-035530 93 ZaffagniniGMartensS

On the other hand, overexpression of Nrf2 (transcriptional regulator of seleno-GPxs) contributed to the increase in the radioresistance and stemness in glioma stem cells (GSCs) by upregulating GPx1 and decreasing the cellular ROS level